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I'm an ocean microbiologist at the University of Tennessee,
and I want to tell you guys about some microbes
that are so strange and wonderful
that they're challenging our assumptions about what life is like on Earth.
So I have a question.
Please raise your hand if you've ever thought it would be cool
to go to the bottom of the ocean in a submarine?
Yes.
Most of you, because the oceans are so cool.
Alright, now -- please raise your hand
if the reason you raised your hand to go to the bottom of the ocean
is because it would get you a little bit closer
to that exciting mud that's down there.
(Laughter)
Nobody.
I'm the only one in this room.
Well, I think about this all the time.
I spend most of my waking hours
trying to determine how deep we can go into the Earth
and still find something, anything, that's alive,
because we still don't know the answer to this very basic question
about life on Earth.
So in the 1980s, a scientist named John Parkes, in the UK,
was similarly obsessed,
and he came up with a crazy idea.
He believed that there was a vast, deep, and living microbial biosphere
underneath all the world's oceans
that extends hundreds of meters into the seafloor,
which is cool,
but the only problem is that nobody believed him,
and the reason that nobody believed him
is that ocean sediments may be the most boring place on Earth.
(Laughter)
There's no sunlight, there's no oxygen,
and perhaps worst of all,
there's no fresh food deliveries for literally millions of years.
You don't have to have a PhD in biology
to know that that is a bad place to go looking for life.
(Laughter)
But in 2002, [Steven D'Hondt] had convinced enough people
that he was on to something that he actually got an expedition
on this drillship, called the JOIDES Resolution.
And he ran it along with Bo Barker Jørgensen of Denmark.
And so they were finally able to get
good pristine deep subsurface samples
some really without contamination from surface microbes.
This drill ship is capable of drilling thousands of meters underneath the ocean,
and the mud comes up in sequential cores, one after the other --
long, long cores that look like this.
This is being carried by scientists such as myself who go on these ships,
and we process the cores on the ships and then we send them home
to our home laboratories for further study.
So when John and his colleagues
got these first precious deep-sea pristine samples,
they put them under the microscope,
and they saw images that looked pretty much like this,
which is actually taken from a more recent expedition
by my PhD student, Joy Buongiorno.
You can see the hazy stuff in the background.
That's mud. That's deep-sea ocean mud,
and the bright green dots stained with the green fluorescent dye
are real, living microbes.
Now I've got to tell you something really tragic about microbes.
They all look the same under a microscope,
I mean, to a first approximation.
You can take the most fascinating organisms in the world,
like a microbe that literally breathes uranium,
and another one that makes rocket fuel,
mix them up with some ocean mud,
put them underneath a microscope,
and they're just little dots.
It's really annoying.
So we can't use their looks to tell them apart.
We have to use DNA, like a fingerprint,
to say who is who.
And I'll teach you guys how to do it right now.
So I made up some data, and I'm going to show you some data that are not real.
This is to illustrate what it would look like
if a bunch of species were not related to each other at all.
So you can see each species
has a list of combinations of A, G, C and T,
which are the four sub-units of DNA,
sort of randomly jumbled, and nothing looks like anything else,
and these species are totally unrelated to each other.
But this is what real DNA looks like,
from a gene that these species happen to share.
Everything lines up nearly perfectly.
The chances of getting so many of those vertical columns
where every species has a C or every species has a T,
by random chance, are infinitesimal.
So we know that all those species had to have had a common ancestor.
They're all relatives of each other.
So now I'll tell you who they are.
The top two are us and chimpanzees,
which y'all already knew were related, because, I mean, obviously.
(Laughter)
But we're also related to things that we don't look like,
like pine trees and Giardia, which is that gastrointestinal disease
you can get if you don't filter your water while you're hiking.
We're also related to bacteria like E. coli and Clostridium difficile,
which is a horrible, opportunistic pathogen that kills lots of people.
But there's of course good microbes too, like Dehalococcoides ethenogenes,
which cleans up our industrial waste for us.
So if I take these DNA sequences,
and then I use them, the similarities and differences between them,
to make a family tree for all of us
so you can see who is closely related,
then this is what it looks like.
So you can see clearly, at a glance,
that things like us and Giardia and bunnies and pine trees
are all, like, siblings,
and then the bacteria are like our ancient cousins.
But we're kin to every living thing on Earth.
So in my job, on a daily basis,
I get to produce scientific evidence against existential loneliness.
So when we got these first DNA sequences,
from the first cruise, of pristine samples from the deep subsurface,
we wanted to know where they were.
So the first thing that we discovered is that they were not aliens,
because we could get their DNA to line up with everything else on Earth.
But now check out where they go on our tree of life.
The first thing you'll notice is that there's a lot of them.
It wasn't just one little species
that managed to live in this horrible place.
It's kind of a lot of things.
And the second thing that you'll notice,
hopefully, is that they're not like anything we've ever seen before.
They are as different from each other
as they are from anything that we've known before
as we are from pine trees.
So John Parkes was completely correct.
He, and we, had discovered a completely new and highly diverse
microbial ecosystem on Earth
that no one even knew existed before the 1980s.
So now we were on a roll.
The next step was to grow these exotic species in a petri dish
so that we could do real experiments on them
like microbiologists are supposed to do.
But no matter what we fed them,
they refused to grow.
Even now, 15 years and many expeditions later,
no human has ever gotten a single one of these exotic deep subsurface microbes
to grow in a petri dish.
And it's not for lack of trying.
That may sound disappointing,
but I actually find it exhilarating,
because it means there are so many tantalizing unknowns to work on.
Like, my colleagues and I got what we thought was a really great idea.
We were going to read their genes like a recipe book,
find out what it was they wanted to eat and put it in their petri dishes,
and then they would grow and be happy.
But when we looked at their genes,
it turns out that what they wanted to eat was the food we were already feeding them.
So that was a total wash.
There was something else that they wanted in their petri dishes
that we were just not giving them.
So by combining measurements from many different places
around the world,
my colleagues at the University of Southern California,
Doug LaRowe and Jan Amend,
were able to calculate that each one of these deep-sea microbial cells
requires only one zeptowatt of power,
and before you get your phones out, a zepto is 10 to the minus 21,
because I know I would want to look that up.
Humans, on the other hand,
require about 100 watts of power.
So 100 watts is basically if you take a pineapple
and drop it from about waist height to the ground 881,632 times a day.
If you did that and then linked it up to a turbine,
that would create enough power to make me happen for a day.
A zeptowatt, if you put it in similar terms,
is if you take just one grain of salt
and then you imagine a tiny, tiny, little ball
that is one thousandth of the mass of that one grain of salt
and then you drop it one nanometer,
which is a hundred times smaller than the wavelength of visible light,
once per day.
That's all it takes to make these microbes live.
That's less energy than we ever thought would be capable of supporting life,
but somehow, amazingly, beautifully,
it's enough.
So if these deep-subsurface microbes
have a very different relationship with energy than we previously thought,
then it follows that they'll have to have
a different relationship with time as well,
because when you live on such tiny energy gradients,
rapid growth is impossible.
If these things wanted to colonize our throats and make us sick,
they would get muscled out by fast-growing streptococcus
before they could even initiate cell division.
So that's why we never find them in our throats.
Perhaps the fact that the deep subsurface is so boring
is actually an asset to these microbes.
They never get washed out by a storm.
They never get overgrown by weeds.
All they have to do is exist.
Maybe that thing that we were missing in our petri dishes
was not food at all.
Maybe it wasn't a chemical.
Maybe the thing that they really want,
the nutrient that they want, is time.
But time is the one thing that I'll never be able to give them.
So even if I have a cell culture that I pass to my PhD students,
who pass it to their PhD students, and so on,
we'd have to do that for thousands of years
in order to mimic the exact conditions of the deep subsurface,
all without growing any contaminants.
It's just not possible.
But maybe in a way we already have grown them in our petri dishes.
Maybe they looked at all that food we offered them and said,
"Thanks, I'm going to speed up so much
that I'm going to make a new cell next century.
Ugh.
(Laughter)
So why is it that the rest of biology moves so fast?
Why does a cell die after a day
and a human dies after only a hundred years?
These seem like really arbitrarily short limits
when you think about the total amount of time in the universe.
But these are not arbitrary limits.
They're dictated by one simple thing,
and that thing is the Sun.
Once life figured out how to harness the energy of the Sun
through photosynthesis,
we all had to speed up and get on day and night cycles.
In that way, the Sun gave us both a reason to be fast
and the fuel to do it.
You can view most of life on Earth like a circulatory system,
and the Sun is our beating heart.
But the deep subsurface is like a circulatory system
that's completely disconnected from the Sun.
It's instead being driven by long, slow geological rhythms.
There's currently no theoretical limit on the lifespan of one single cell.
As long as there is at least a tiny energy gradient to exploit,
theoretically, a single cell could live
for hundreds of thousands of years or more,
simply by replacing broken parts over time.
To ask a microbe that lives like that to grow in our petri dishes
is to ask them to adapt to our frenetic, Sun-centric, fast way of living,
and maybe they've got better things to do than that.
(Laughter)
Imagine if we could figure out how they managed to do this.
What if it involves some cool, ultra-stable compounds
that we could use to increase the shelf life
in biomedical or industrial applications?
Or maybe if we figure out the mechanism that they use
to grow so extraordinarily slowly,
we could mimic it in cancer cells and slow runaway cell division.
I don't know.
I mean, honestly, that is all speculation,
but the only thing I know for certain
is that there are a hundred billion billion billlion
living microbial cells
underlying all the world's oceans.
That's 200 times more than the total biomass of humans on this planet.
And those microbes have a fundamentally different relationship
with time and energy than we do.
What seems like a day to them
might be a thousand years to us.
They don't care about the Sun,
and they don't care about growing fast,
and they probably don't give a damn about my petri dishes ...
(Laughter)
but if we can continue to find creative ways to study them,
then maybe we'll finally figure out what life, all of life, is like on Earth.
Thank you.
(Applause)
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【TED】This deep-sea mystery is changing our understanding of life | Karen Lloyd

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黃浩瑋 2018 年 3 月 1 日 に公開

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