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Glycogen storage disease is the result of defects in the processing of glycogen synthesis
or breakdown within muscles, liver, and other cell types. GSD has two classes of cause:
genetic and acquired. Genetic GSD is caused by any inborn error of metabolism involved
in these processes. In livestock, acquired GSD is caused by intoxication with the alkaloid
castanospermine. Overall, according to a study in British Columbia,
approximately 2.3 children per 100 000 births have some form of glycogen storage disease.
In the United States, they are estimated to occur in 1 per 20,000-25,000 births. A Dutch
study estimated it to be 1 in 40,000. Types
There are eleven distinct diseases that are commonly considered to be glycogen storage
diseases. GSD type VIII: In the past, considered a distinct
condition. Now classified with VI. Has been described as X-linked recessive.
GSD type X: In the past, considered a distinct condition. Now classified with VI.
References
External links Asociación Española de Enfermos de Glucogenosis