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  • Over 100,000 metric tons of caffeine are consumed

  • around the world every year.

  • That's equivalent to the weight of 14 Eiffel Towers.

  • Most of this caffeine is consumed in coffee and tea,

  • but it's also ingested in some sodas,

  • chocolate,

  • caffeine pills,

  • and even beverages labeled decaf.

  • Caffeine helps us feel alert, focused, happy, and energetic,

  • even if we haven't had enough sleep.

  • But it can also raise our blood pressure, and make us feel anxious.

  • It's the world most widely used drug.

  • So how does it keep us awake?

  • Caffeine evolved in plants where it serves a few purposes.

  • In high doses, as it's found in the leaves and seeds of certain species,

  • it's toxic to insects.

  • But when they consume it in lower doses, as it's found in nectar,

  • it can actually help them remember and revisit flowers.

  • In the human body, caffeine acts as a stimulant for the central nervous system.

  • It keeps us awake by blocking one of the body's key sleep-inducing molecules,

  • a substance called adenosine.

  • Your body needs a constant supply of energy,

  • which it gets by breaking down a high-energy molecule called ATP.

  • In the process,

  • it liberates adenosine, ATP's chemical backbone.

  • Neurons in your brain have receptors perfectly tailored to this molecule.

  • When adenosine docks to these receptors,

  • it activates a cascade of biochemical reactions

  • that cause neurons to fire more sluggishly

  • and slow the release of important brain-signaling molecules.

  • In other words, you get sleepy.

  • Caffeine is what's called an adenosine receptor antagonist.

  • That means it derails this process of slowing your neurons down

  • by blocking adenosine receptors.

  • Caffeine and adenosine have a similar molecular structure,

  • close enough that caffeine can wedge into the adenosine receptors,

  • but not close enough to activate them.

  • To summarize, adenosine inhibits your neurons.

  • Caffeine inhibits the inhibitor, so it stimulates you.

  • Caffeine can also boost positive feelings.

  • In some neurons, the adenosine receptors

  • are linked to receptors for another molecule called dopamine.

  • One of dopamine's roles in the brain is to promote feelings of pleasure.

  • When adenosine docks in one of these paired receptors,

  • that can make it harder for dopamine to fit in its own spot,

  • interrupting its mood-lifting work.

  • But when caffeine takes adenosine's place, it doesn't have the same effect,

  • and dopamine can slide in.

  • There's evidence that caffeine's effects on adenosine and dopamine receptors

  • can have long-term benefits, too, reducing the risk of diseases

  • like Parkinson's, Alzheimer's, and some types of cancer.

  • Caffeine can also ramp up the body's ability to burn fat.

  • In fact, some sports organizations think

  • that caffeine gives athletes an unfair advantage

  • and have placed limits on its consumption.

  • From 1972 until 2004,

  • Olympic athletes had to stay below a certain blood-caffeine concentration

  • to compete.

  • Of course, not all of caffeine's effects are so helpful.

  • It might make you feel better and more alert,

  • but it can also raise your heart rate and blood pressure,

  • cause increased urination or diarrhea,

  • and contribute to insomnia and anxiety.

  • Plus, the foods and beverages caffeine is found in

  • have their own impacts on your body that have to be taken into account.

  • Your brain can adapt to regular consumption of caffeine.

  • If your adenosine receptors are perpetually clogged,

  • your body will manufacture extra ones.

  • That way, even with caffeine around,

  • adenosine can still do its job of signaling the brain to power down.

  • That's why you may find you need to consume more and more caffeine

  • to feel as alert.

  • There are more and more adenosine receptors to block.

  • It's also why if you suddenly quit caffeine,

  • you may experience an unpleasant withdrawal.

  • With plenty of receptors and no competition,

  • adenosine can work overtime,

  • causing symptoms like headaches,

  • tiredness,

  • and depressed moods.

  • But in a few days, the extra adenosine receptors will disappear,

  • your body will readjust,

  • and you'll feel just as alert as ever,

  • even without an infusion of the world's most popular stimulant.

Over 100,000 metric tons of caffeine are consumed

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TED-ED】カフェインはどうやって私たちを目覚めさせているのか?- ハナン・カシム (【TED-Ed】How does caffeine keep us awake? - Hanan Qasim)

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    wangsir に公開 2021 年 01 月 14 日
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