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  • In this video, I want to provide an overview

  • of neuron structure.

  • Neurons in adults have a soma.

  • It's also called a cell body-- soma.

  • And they have processes called neurites,

  • which are divided into dendrites and axons.

  • Dendrites are usually short, branched processes

  • that are often covered in small spines that

  • increase their surface area and perform some other functions.

  • So these are dendrites.

  • And then the other neurite they have

  • is called an axon, which is usually

  • long and unbranched until it reaches its end.

  • So this is the axon.

  • The area where the axon leaves the soma

  • is called the axon hillock.

  • The axon may be short or it may be very long, up to one meter

  • or more.

  • And it usually is unbranched for most or all of that length,

  • until it gets to the end, in these structures,

  • which are called axon terminals.

  • And at this point, it will often branch and create

  • multiple axon terminals.

  • The first part of the axon is called

  • the axon initial segment.

  • Or it's also called the trigger zone.

  • And we'll get into the reason for that in the next video.

  • Axons can be so long that they are

  • dependent on systems that transport substances

  • from the soma, which contains most of the organelles,

  • to the axon terminals, and vice versa.

  • Things have to be transported both directions.

  • And the axon is dependent on those systems.

  • Large axons are usually wrapped in a sheath

  • of a material called myelin.

  • And axons that have a myelin sheath

  • have little gaps between these segments

  • of myelin call nodes of Ranvier.

  • So the sheath I've drawn in yellow

  • is the myelin, each of these little segments of sheath here.

  • And these gaps that regularly interrupt the sheath

  • are called nodes of Ranvier, these little gaps in the myelin

  • sheath.

  • The axon terminals will come very

  • close to the target cells of the neuron.

  • And I'll just draw it here.

  • So these are the target cells.

  • And these targets cells may be another neuron,

  • they may be a muscle cell, or they may be a gland cell.

  • A few neurons even have axons that terminate on capillaries,

  • to secrete substances called hormones into the bloodstream.

  • The place where an axon terminal comes

  • close to touching the target cell is called a synapse.

  • This is a pretty typical structure for a neuron.

  • But there are multiple structural types

  • of neurons, each of which can be further divided into subtypes.

  • So let's go over some of the big categories

  • of structural types of neurons.

  • In the central nervous system, neurons

  • start as neural stem cells, which

  • turn into most of the cell types of the central nervous system.

  • And these neural stem cells then differentiate

  • into cells called neuroblasts.

  • And don't worry about the details here.

  • Because we'll go into a lot more detail

  • in other videos on development of the nervous system.

  • But neural stem cells and neuroblasts

  • look pretty similar.

  • They're basically just shapeless cells without processes.

  • Neural stem cells can become almost any neural cell

  • of the central nervous system, while neuroblasts can only

  • become neurons.

  • Neuroblasts will then migrate away

  • from the neural stem cells to the location

  • that their somas will have after development.

  • Neuroblasts then extend a process, which is an axon,

  • toward their target cell.

  • And that axon is tipped with this structure called a growth

  • cone-- growth cone.

  • The axon growth cone follows guidance cues

  • in the environment until it reaches

  • the target cell of the neuron.

  • A similar process occurs for neurons

  • in the peripheral nervous system.

  • But the original and the migrating cells

  • for those neurons are neural crest cells, instead of

  • neural stem cells and neuroblasts.

  • Neurons at this stage have only one process, which is an axon.

  • So they are now called unipolar neurons-- unipolar.

  • That's the structural type of this neuron

  • because there's one pole to the cell, one process giving

  • a sense of direction on this otherwise shapeless cell.

  • Unipolar neurons are present in humans,

  • mainly during development.

  • The next structural type of neuron has a soma.

  • And it has one axon.

  • But it also has one dendrite.

  • So since this structural type of neuron

  • has two processes, or two poles, it's

  • called a bipolar neuron-- bipolar.

  • The next structural type of neuron

  • has a soma, just like the others, and one axon.

  • But it has multiple dendrites.

  • And so since it's going to have multiple poles,

  • it's called a multipolar neuron-- multipolar.

  • And this is the most common structural type

  • of neuron in adult humans.

  • The last big category of structural types of neurons

  • is a little different.

  • It has a soma, like all the rest.

  • And then it has one a short process

  • coming out of the soma, that then divides

  • into two long processes going in different directions.

  • And these are both axons.

  • The axon bringing information in from the periphery

  • is called the peripheral axon.

  • And the axon bringing information

  • into the central nervous system is called the central axon.

  • The very end of the peripheral axon acts a lot like dendrites

  • do on the other structural types of neurons.

  • And we'll start to go over the function of dendrites and axons

  • in the next video.

  • And then this part of the peripheral axon near the end

  • is the axon initial segment, where the trigger zone, just

  • like this part is on a multipolar neuron

  • close to the soma.

  • And just like in these neurons where this is the trigger zone,

  • and then the end of the axon has the axon terminals,

  • in this type of neuron this is the trigger zone of the axon.

  • And then the axon terminals are all the way

  • at this end of the central axon.

  • So this type of neuron has a big, long, funny name.

  • It's called a pseudounipolar neuron-- pseudounipolar.

  • And the reason is that it's kind of, sort

  • of like a unipolar neuron, with only one process

  • coming out of the soma.

  • But that little short process immediately

  • splits into these two long axons.

  • So it's really a different shape than the unipolar neurons.

In this video, I want to provide an overview

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ニューロン構造の概要 (Overview of neuron structure)

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    Alvin He に公開 2021 年 01 月 14 日
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