Name: #08 ケビン・アハーンのBB450/550のための生化学ヘモグロビン講義 (#08 Biochemistry Hemoglobin Lecture for Kevin Ahern's BB 450/550)
Uploaded: 2021-01-14T05:15:43.000Z
Duration: 50 min 43 s
Description: VoiceTubeの動画で発音を聞きながら英語表現を覚えよう！学べる英語：

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様態の副詞

Ahern: We are moving rapidly through stuff

and I finally sat down and looked at when the exam is

I'm guessing you guys wouldn't be ready for it this Friday?

I want to say about characterizing proteins

The things that are there are really more biophysical in nature

last time I talked about MALDI-TOF and MALDI-TOF

is a fantastic method as I say that I realize

I will get that figure posted showing you the set up

and you can hopefully see it better than my words can describe.

are a couple other very powerful techniques

and you should be able to understand why they're useful for us.

are X-Ray crystallography and nuclear magnetic resonance.

at least with nuclear magnetic resonance,

I'm guessing in your organic chemistry class.

Has anyone had exposure to X-Ray crystallography before?

are extraordinarily useful for helping us to understand

I always tell the story when I give a tour of our facilities

in ALS in Biochemstry and biophysics to students

that using the tools of X-Ray crystallography

that might exist in an enzyme that has 10,000 or 50,000 atoms.

When we think about how drugs get designed,

the design of drugs is happening increasingly

as a result of the molecular knowledge of the structure

If I know the position or I know the structure

the place where the reaction is catalyzed,

That knowledge of structure is really valuable for us

And there are purposes aside from designing drugs as well.

X-Ray crystallography arises from the fact

which means they get bent when they encounter electron clouds.

That diffraction process is depicted here.

and a crystal is a as you guys see crystals

you don't think at a molecular level what a crystal is,

but a crystal is a perfectly packed homogenous molecule

That is all the molecules in there are the same composition

and they're organized in a regular fashion.

That regular repeat is what gives rise to the crystal itself.

The process of making a crystal for a lot of X-ray crystal analyses

is actually the thing that takes the longest.

A lot of different, there's no one formula for making a crystal.

Different proteins crystallize in different to way.

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#08 ケビン・アハーンのBB450/550のための生化学ヘモグロビン講義 (#08 Biochemistry Hemoglobin Lecture for Kevin Ahern's BB 450/550)

state

structure

protein

molecule