Name: Podcast: What Is H. Pylori?（Podcast: What Is H. Pylori?）
Uploaded: 2022-10-24T01:46:33.000Z
Duration: 13 min 30 s
Description: VoiceTubeの動画で発音を聞きながら英語表現を覚えよう！学べる英語：

法助動詞 （推測）

Well, today we're going to give you more power

It's called Helicobacter Pylori, or H. pylori, for short.

And it can cause big problems in your stomach.

For decades, Japan has had the longest life expectancy

in the world, while spending just a fraction on healthcare

This longevity has been attributed in part to Japanese dietary patterns,

which are thought to have contributed to their comparatively

Japan has historically had amongst the lowest rates

of colon cancer, breast cancer, ovarian cancer, prostate cancer,

Japan, however, has among the highest rates of stomach cancer.

Yes, Japanese men may have had seven times less prostate cancer

than Americans but got six times more stomach cancer.

Is there some Achilles' heel in the Japanese diet?

One of the first theories, proposed in the 1970s,

was that it was the talc used to polish white rice

That was the case with ovarian cancer, which led to billions

in damages against Johnson & Johnson's baby powder,

but that did not appear to be the case with stomach cancer.

Is it just genetics? No. Studies on Japanese migrants

show that as they and their children Westernize

their stomach cancer rates drop accordingly.

Well, the most well-established risk factor for stomach cancer

the lining of the stomach and causes the chronic inflammation

H. pylori infection is considered a Group 1 carcinogen, indicating

our highest level of certainty that it indeed causes cancer.

Korea and Japan have the highest rates of stomach cancer

and among the highest incidence of H. pylori infection.

Countries such as Nigeria had even more H. pylori,

but only a fraction of Japan's stomach cancer rates.

H. pylori is twice as prevalent in India than Japan, yet Indians get

Obviously, H. pylori alone can't explain Japan's epidemic.

most people with H. pylori don't get cancer.

H. pylori is one of the most common human infections.

It's been estimated that half of the world's adult population

is infected with H. pylori, yet half of us don't get stomach cancer.

There must be some kind of co-factor in countries like Korea and Japan

that explains their elevated cancer rates.

The inflammation caused by H. pylori may just set the stage

for cancer formation, increasing the susceptibility

of the stomach lining to dietary carcinogens.

But what's so carcinogenic about Korean and Japanese diets?

Studies that have compared the dietary components

of different Asian populations with similar H. pylori rates,

but dramatically different stomach cancer rates, have suggested

preserved, salted foods—both fish and vegetables—as the culprits.

Fresh vegetables and fruits, on the other hand, were associated

with an 85% reduction in stomach cancer odds,

whereas consumption of fresh fish doesn't appear associated

A review of 60 studies found the consumption

of pickled foods was associated with significantly higher rates

of stomach cancer, though more so in Korea than Japan,

perhaps because per-capita Korean consumption

You can't know for sure though until you...put it to the test.

Pickled vegetable extracts can cause DNA damage in cells in a petri dish,

Researchers in Vancouver fed people 30 ounces of fukujinzuke —

assorted vegetables pickled in soy sauce —

or pickled cucumbers over a three-day period.

Biopsies taken from their stomach lining before the experiment started

were normal, as were the biopsies taken after eating

But after just a few days of consuming pickled vegetables,

moderate to severe tissue abnormalities were found,

The consumption of non-fermented soy foods, such as tofu, edamame,

and soymilk is linked to a lower risk of stomach cancer in Japan,

whereas no association was found with fermented soy foods,

The protection afforded by soy foods was attributed

to the anti-inflammatory and anti-oxidant effects

Salt itself isn't considered a direct carcinogen, but it may

damage the stomach lining, thin the protective mucus layer,

enhance H. pylori colonization, enhance the penetration

of carcinogens, and enhance the formation of carcinogens.

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Podcast: What Is H. Pylori?（Podcast: What Is H. Pylori?）

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