Name: #第24回 ケビン・アハーンのBB450/550のための生化学グルコネジェネシス講義 (#24 Biochemistry Gluconeogenesis Lecture for Kevin Ahern's BB 450/550)
Uploaded: 2021-01-14T05:08:11.000Z
Duration: 46 min 20 s
Description: VoiceTubeの動画で発音を聞きながら英語表現を覚えよう！学べる英語：

I'm guessing if I gave everybody who came to class

an A today then they'd never come to class again.

Which would kind of be a self-defeating thing, right?

What she should say is, "Ahern, you're a scientist,

"let's do the experiment and fight out," right?

Student: Yeah, you could get in a lot of trouble.

Ahern: No, actually the way I do that is I go to a place

and you have to show an ID so it's not my responsibility.

I hope everybody's got a big Thanksgiving planned.

and would like to come over, give us a holler

and I'll let you know where we're going to live and everything,

we've got plenty of turkey and other things.

because we're going to be thinking of the making of glucose.

that's been something you've dreamed of doing

and you're going to get that dream today.

Glucose synthesis is an interesting process.

The phenomena of course is known as gluconeogenesis

and it is a pathway that is very similar,

It's very similar to the reverse of glycolysis.

However, there are important differences and specifically,

I'm sorry, specifically that there are 3 reactions.

There are 3 reactions in gluconeogenesis,

So gluconeogenesis has 11 steps, glycolysis had 10.

One of the steps takes two steps to get around.

If you learned glycolysis, gluconeogenesis for 8 of the steps,

for 7 of the steps is identical to glycolysis

Same enzymes, same intermediates going to the opposite direction.

Three of the steps that are in glycolysis

Before I take a look at that, I'll show you something

your book is distracted by and that is this process here,

which is the making of glucose from glycerol.

Why do we care about the making of glucose from glycerol.

One of the reasons we care about the making of glucose

that the only portion of the fat molecule

that can be converted directly into glucose is the glycerol.

We don't convert fat into glucose for the most part,

I just show you this, I'm not going to go through

and expect you to memorize these are anything,

but just show you that glycerol is a 3-carbon molecule.

And of course, once it's dihydroxyacetone phosphate,

going into making glucose via gluconeogenesis.

And we see this, this is a phenomena you've seen before.

We saw how other sugars entered glycolysis

and gotten broken down by being converted

We saw, for example, fructose got converted

into fructose-6-phosphate and then got metabolized

In this case, we see glycerol being converted

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#第24回ケビン・アハーンのBB450/550のための生化学グルコネジェネシス講義 (#24 Biochemistry Gluconeogenesis Lecture for Kevin Ahern's BB 450/550)

molecule

reaction

energy

enzyme

#第24回 ケビン・アハーンのBB450/550のための生化学グルコネジェネシス講義 (#24 Biochemistry Gluconeogenesis Lecture for Kevin Ahern's BB 450/550)

molecule

reaction

energy

enzyme

#第24回ケビン・アハーンのBB450/550のための生化学グルコネジェネシス講義 (#24 Biochemistry Gluconeogenesis Lecture for Kevin Ahern's BB 450/550)