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  • Diabetes is one of the fastest growing health crises of our time,

  • in Britain, the National Health Service spends 10 billion pounds per year treating it,

  • that's almost 10% of the entire National Health budget.

  • By 2040, it's estimated that one in 10 people around the world will have the disease,

  • three decades of healthy lifestyle advice have failed to make an impact.

  • Could surgery be the answer?

  • Been a fisherman all my life.

  • I can't tell you how much I miss the sea,

  • I love my wife and children obviously,

  • but fishing is a passion, it isn't just a job.

  • Peter Hansell is 68.

  • A few years ago, he was diagnosed with type two diabetes.

  • When I was diagnosed, I didn't think it would have the restrictions it had on my life,

  • it just wasn't safe for me to be at sea,

  • so diabetes has stopped me working, which upsets me greatly.

  • Type two diabetes is a serious condition in which the body can't use insulin properly,

  • 90% of people with diabetes have type two,

  • type one is much rarer and usually develops in childhood.

  • The prognosis is that parts of my body will deteriorate over time, my kidneys, my heart.

  • I've always had tons of get up and go,

  • but I'm afraid the get up and go has got up and gone.

  • Globally the number of people with type two diabetes has quadrupled in the past four decades,

  • it's been branded as a lifestyle illness brought on by poor diet and lack of exercise.

  • Obesity is a major risk factor,

  • but one doctor is convinced that the disease is misunderstood.

  • If it were as simple as telling people to eat less and exercising more,

  • we have been giving this message for the past 30 years

  • and as a result, we haven't seen any change and the epidemic has continued to grow.

  • Professor Francesco Rubino specializes in weight loss surgery,

  • he's performed hundreds of gastric bypass operations on obese patients, but Rubino has discovered that gastric surgery has a profound and unexpected side effect.

  • I found that many of the patients, who have bariatric operations would experience a complete remission of diabetes almost overnight,

  • to me, that was too much to be explained by weight loss alone and I thought what if there is something else?

  • Dr. Rubino is now going to operate on Peter,

  • not because he's obese, but to treat his diabetes by changing the anatomy of his gut.

  • Rubino believes that a section of the small intestine doesn't work properly in people with diabetes.

  • Peter's stomach will be divided and rerouted,

  • so that food no longer passes through the faulty section.

  • Something happens in the duodenum,

  • which contributes to the mechanism of diabetes and by bypassing that segment, we're bypassing what could be the source of the problem.

  • When food moves through the small intestine,

  • a complex hormone signaling system tells the brain to stop eating and stimulates the pancreas to produce insulin.

  • A fault in this signaling system would make it extremely difficult for the patient to control their eating

  • and could explain why the body can't regulate insulin properly.

  • Peter stands a very good chance of having a complete remission of diabetes

  • and this is an effect that was not even conceived as possible just until a few years ago.

  • The effect is so striking, that in 2016,

  • international medical guidelines were changed to include surgery as a main treatment option for some diabetes patients, but very few have come forward.

  • Despite the evidence, suggesting that these interventions are so effective and in many cases, they're lifesaving,

  • there are probably .1 to 1% of individuals, who meet the criteria for surgery who actually have access to it.

  • Type two diabetes is widely viewed as a lifestyle disease, that patients can control on their own without the need for surgery,

  • but Rubino believes this is a misconception.

  • Having an operation is not an experience that everybody would be prepared to have,

  • however the evidence we have so far has shown time and again,

  • or once you have very severe obesity,

  • changing your lifestyle alone is not going to bring the benefits that are needed.

  • In clinical trials,

  • Rubino is testing other ways to prevent food from interacting with the faulty section of the intestine,

  • such as plastic tubing or eradicating cells from the gut wall.

  • The hope is that in the future, patients like Peter won't need to have invasive surgery.

  • Seven weeks after the operation and Peter's health has taken a dramatic turn.

  • I just feel good, I can just do what I want, I've got a life again.

  • I can't thank Professor Rubino and his team enough for what they did for me,

  • I haven't took any insulin since.

  • For now at least, Peter's diabetes is in remission.

  • Surgery alone can't halt the epidemic,

  • diabetes rates are rising in almost every country,

  • but only a few have the resources for surgery.

  • Prevention through better diet and lifestyle is vital,

  • but if surgery can uncover the cause of diabetes, perhaps a cure will follow.

Diabetes is one of the fastest growing health crises of our time,

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糖尿病の治療法は手術で見つかる?| エコノミスト (Can a cure for diabetes be found through surgery? | The Economist)

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    歐小拉 に公開 2021 年 01 月 14 日
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