Name: 癌における細胞周期制御の喪失 (Loss of Cell Cycle Control in Cancer)
Uploaded: 2021-01-14T06:31:08.000Z
Duration: 3 min 45 s
Description: VoiceTubeの動画で発音を聞きながら英語表現を覚えよう！学べる英語：

There are other, higher levels of regulation that occur here

and I started to talk about them when I mentioned our

RB protein. So, control of the cell cycle

occurs on a higher level with a couple of

One of the main proteins we talk about that

It's even got a nickname: it's the "guardian of the genome."

It's so important, actually, that Science Magazine called it,

Theobromine, the main molecule that's in chocolate,

hasn't even gotten this honor yet. So it shows you

how important p53 is. It's more important than chocolate.

P53 will bind DNA directly to produce proteins that block

with the function of P53, and these proteins are considered

tumor suppressor genes, so RB is a protein that is

produced from a tumor suppressor gene, just like p53,

so I'll write that down here. These proteins are considered

tumor suppressor genes... They're made from

tumor suppressor genes I should rather say.

These proteins are made from tumor suppressor genes,

if they are defected, or if they have a mutation in them

(repeats) defected or if they have a loss of function,

what ends up happening is that you tend to get cancer.

Cancer, which I think you and I can both agree is not

a good thing to have. So, it is very important

To illustrate how important that is, if you look at

p53, greater than 50% of tumors have a defect in p53.

RB got its name because a defect in RB would lead to a

tumor of the eye, known as retino-that's where you got the R-

retinoblastoma, which is why these two proteins are

P21 is very unusual in that it doesn't actually lead to

scientists have found that mice that are without p21

have the ability to regenerate their limbs.

P21 lack causes the ability to regenerate their limbs,

So we're all still trying to figure out exactly

are essential for making sure that we regulate

the cell cycle so we don't just go to the

We want to make sure that we only divide when it's appropriate,

when a cell is ready to, or if it's even a cell that

is supposed to divide in the first place.

Because, as we'll see in our next couple of videos,

mitosis, or cell division, requires a lot of energy

So we need to make sure it's the right time to divide.