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  • What if our body could stay in its prime forever?

  • What if we could be biologically immortal like a hydra,

  • a tiny freshwater creature that can continuously renew its cells?

  • Or what if we could turn back the clock like some jellyfish that never die

  • but revert to an earlier form and go through life all over again?

  • But most cells in our body aren't built to last a lifetime.

  • They're damaged all the time by everything from ultraviolet rays to poor nutrition.

  • When this happens, cells make copies of their chromosomes,

  • which contain our DNA, and divide into healthy new cells.

  • But at some point, cells lose their ability to replicate.

  • With each cell division, the ends of our chromosomes get a bit shorter.

  • These end regions don't actually hold active genes.

  • They're protective caps called telomeres.

  • But once telomeres shrink past a certain point,

  • the cells can't divide anymore and enter a state called senescence.

  • There's nothing inherently bad about cells becoming senescent

  • Senescent cells just behave differently from cells that can still divide.

  • They also secrete a variety of chemicals that activate the immune system.

  • When we're young and healthy,

  • this can help us recover from injury, for instance.

  • But the issue is when the body doesn't eliminate senescent cells quickly

  • enough and they make neighboring cells go senescent as well.

  • That begins a domino effect that can lead to chronic inflammation.

  • Over time, this makes our brain work

  • slower and causes our body to start to deteriorate.

  • We become more susceptible to disease and we die.

  • But does it really have to happen this way?

  • Experts have a lot of theories about why we age.

  • One of the most popular ideas is that human bodies

  • only have a limited amount of lifetime energy, and we spend lots of this

  • energy prioritizing reproductive functions.

  • Scientists call this the "Disposable Soma Theory." The idea is that our

  • soma, or body, is disposable while our germ line lives on.

  • Not everyone wants to reproduce, though.

  • For those who would prefer a few extra years to having children,

  • there may be ways to shift your body's energy allocation,

  • decreasing your fertility to extend your lifespan.

  • But if everyone could suddenly choose between fertility and long life,

  • it could lead to a host of ethical issues.

  • Whose lives are extended and who can reproduce?

  • And if you try to reach a sort of compromise,

  • extending your lifespan while still having kids, you might just end up

  • increasing your children's or grandchildren's risk of mutations,

  • which could end up causing major issues in your descendants.

  • It's hard to fight aging because it lies at the very core of our genetic makeup.

  • Short telomeres would be an obvious target for anti-aging interventions.

  • But people with very long telomeres or more telomerase, an enzyme

  • that keeps telomeres long, aren't always better off.

  • Cancer cells can use telomerase to multiply unchecked.

  • And people with excessively

  • long telomeres may be likelier to get lung cancer and brain tumors.

  • Some researchers are trying to prevent cells from reaching senescence

  • or to help the body remove senescent cells more efficiently.

  • But they face a similar problem.

  • They need to target specific cells that induce aging

  • and avoid ones that are benefiting the body.

  • Researchers still have some ideas for extending lifespan though.

  • Among the most popular is moderate caloric restriction.

  • In one study, people who ate 15% fewer calories for two years ended up with a

  • significantly lowered base metabolic rate, an indicator that their body aged less.

  • But this has to be done very carefully because the body needs

  • nutrients to survive and function properly.

  • And while some caloric restriction may extend lifespan, scientists

  • are still investigating whether it could lead to unintended side effects.

  • For instance,

  • animal studies suggest under-eating may decrease gray matter in the brain.

  • Though it doesn't necessarily mean it hurts mental performance.

  • Perhaps, though, longer life isn't the right target.

  • Instead, many researchers are turning their attention to giving people more

  • healthy years, something that's remained a challenge despite medical advances.

  • Chronic diseases are on the rise globally, posing a major strain on health

  • resources and national economies as people live longer.

  • At this point, there aren't many innovative ways to extend

  • your so-called "healthspan" besides obvious factors,

  • such as maintaining a balanced diet, exercise and strong social connections.

  • Beyond that, aging is built into our DNA.

  • And while experts are continuing to explore clever ways to counteract it

  • at a molecular level

  • through drugs or other therapies, our body is never going to be permanent.

What if our body could stay in its prime forever?

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Decoded: Can We Stop Aging?(Decoded: Can We Stop Aging?)

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    林宜悉 に公開 2023 年 07 月 17 日
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