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  • Although everybody forgets, excessive forgetting

  • can be a sign of a more serious problem.

  • Dementia is the term for a decline

  • in memory and other cognitive functions

  • that gets to the point of interfering with daily life.

  • Dementia results from excessive damage

  • to brain tissue, which can be from multiple strokes

  • or other causes.

  • The most common form of dementia is Alzheimer's disease, or AD.

  • Now, the exact cause of AD is still unknown,

  • but we do know that in people with AD,

  • their neurons die off over time.

  • As people with AD lose their neurons and synapses,

  • their cerebral cortex shrinks in size.

  • The earliest symptoms of AD are memory loss, specifically

  • the inability to encode or retrieve recent memories.

  • Subsequent problems include difficulty

  • with attention, planning, semantic memory,

  • and abstract thinking.

  • As the disease progresses, more severe language difficulties

  • may appear, as well as greater memory loss,

  • such as the inability to recognize close family

  • and friends.

  • As the disease continues to progress, people with AD

  • may experience emotional instability and loss of control

  • over their bodily functions.

  • While there are many theories as to the exact cause

  • of the disease, a definitive answer is still unknown,

  • and the disease is terminal.

  • We do know that people with AD experience

  • a buildup of proteins called amyloid plaques in the brain,

  • but how or why those plaques start to build up

  • and exactly what role they play in the disease is still

  • uncertain.

  • Another neurological disorder affecting memory

  • is Korsakoff's syndrome, which is

  • caused by a lack of vitamin B1, or thiamine, in the brain.

  • This disorder is strongly linked to severe malnutrition,

  • eating disorders, or especially alcoholism,

  • because these groups often don't ingest or are

  • unable to process all the nutrients their bodies need,

  • including thiamine.

  • Thiamine is important because it's

  • responsible for converting carbohydrates

  • into the glucose your cells need for energy,

  • and it's especially important for the normal functioning

  • of your neurons.

  • At first, a person developing Korsakoff's syndrome

  • might have damage to certain parts of the brain,

  • resulting in poor balance, abnormal eye movements,

  • mild confusion, and/or memory loss.

  • At this stage, it's actually called

  • Wernicke's encephalopathy, which is

  • the precursor to Korsakoff's syndrome.

  • If Wernicke's encephalopathy is diagnosed in time,

  • then it's possible to reverse the damage,

  • or at least prevent more of it.

  • If untreated, however, the disease

  • will progress into full-blown Korsakoff's syndrome.

  • The main symptom of Korsakoff's syndrome is severe memory loss,

  • and this symptom is often accompanied by confabulation,

  • which is when the patient makes up stories,

  • sometimes to fill in the gaps in his or her memory.

  • Unlike AD, Korsakoff's syndrome is not necessarily progressive.

  • If diagnosed and treated, people can get better.

  • People are often treated with thiamine injections

  • or other medication, and they have

  • to stay on a healthy diet and abstain from alcohol.

  • And some people may also need to re-learn some things.

  • The effectiveness of this treatment

  • really depends on how early the disease is diagnosed

  • and how well the patient follows the treatment guidelines.

Although everybody forgets, excessive forgetting

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アルツハイマー病とコルサコフ症候群|環境の処理|MCAT|カーンアカデミー (Alzheimer's disease and Korsakoff's syndrome | Processing the Environment | MCAT | Khan Academy)

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    Amy.Lin に公開 2021 年 01 月 14 日
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