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  • In terms of computational power, the human brain

  • far surpasses any animal in the animal kingdom.

  • It's what makes us special, but we still

  • don't understand how it arises, and so that's

  • what me and my lab were trying to figure out.

  • The thing that makes our brains so special

  • is the number of connections and the number of neurons.

  • At about 80 to 100 billion neurons,

  • that's about three times more than our closest relatives,

  • the chimpanzees.

  • And so it's thought that during human brain development

  • neuron production really skyrockets.

  • But when and how this happens is completely unknown.

  • So to get the answers to these questions

  • we've turned to growing human brain tissues in the lab.

  • In the past 10 years there's been a revolution

  • in this field, allowing researchers

  • to generate 3D tissues that look just like actual organs.

  • And essentially, it involves taking stem cells, which

  • have this amazing capacity to develop

  • into any tissue of the body, including brain tissue,

  • if we give them the right conditions.

  • And those conditions include a three-dimensional gel,

  • which essentially mimics the surrounding

  • tissue of the developing brain.

  • And what's really amazing about this is that,

  • when these cells are kept in just the right conditions,

  • they will then follow their own natural developmental

  • programme, generating neurons with the same timing

  • and positioning as an actual human developing brain.

  • So because we have these 3D mini brain tissues in a dish,

  • we now have access to human developing brain

  • tissue in a way that was never before possible.

  • We can actually really get hands-on,

  • and start looking inside of them by taking cross-sections,

  • looking at different cell types, and comparing different time

  • points to see what changes over time.

  • We can also do live imaging and actually watch

  • as human neural stem cells do generate neurons,

  • and then watch those neurons position themselves.

  • And this is something that was never before possible.

  • And so at the moment, we can observe these processes

  • very well, but what we'd really like to do

  • is start to challenge the system and look

  • at what's controlling the skyrocketing neuron production

  • that we're so interested in, and get

  • at the root of the question of what

  • makes our brains so unique.

In terms of computational power, the human brain

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ミニ脳が神経科学に革命を起こす方法|理学修士課程 (How mini-brains could revolutionise neuroscience | Masters of Science)

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    林宜悉 に公開 2021 年 01 月 14 日
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