字幕表 動画を再生する 英語字幕をプリント -[Voiceover] An introduction to Mendelian Genetics. Now before we start, let's review the idea that human cells contain 46 chromosomes, which contain the DNA that makes each cell unique. 23 of these chromosomes were inherited from a person's father and 23 were inherited from the mother. We can say that each person's made up of a combination of genetic code from both of their parents. Now sometimes we like to say that we have 23 pairs of chromosomes. Instead of saying that we have 46 total because that way we remind ourselves that for each chromosome we have a maternal and paternal copy. Now the first thing I want to introduce is the term allele. If we have a chromosome here and then an allele is one small section on that chromosome that codes for a specific gene that makes you, you. Since humans have at least two copies of each chromosome, we can say that humans usually have at least two alleles for every specific gene. One allele from their mother and one from their father. Let's look at an example and we'll start by talking about blood type. I'm sure that you've heard that blood types are usually named with letters like A, B, and O. What does that actually mean? Well there's a specific allele that codes for blood type. Let's say that we have this guy here and his alleles both code for blood type A. I'll use the letter A for that. Let's say we have this girl here who has one allele coding for A and another allele coding for blood type O. Now for the guy, he has both alleles coding for blood type A then it's pretty clear that when we check his actual blood type it will be A. For the girl, we're not so sure since she has one of each. Now, I'm going to introduce a couple new terms to you. The first is that since the guy has two alleles that code with the same thing both code for blood type A then we say that this guy is homozygous. Homo means the two alleles are the same, homo the same and zygous refers to mixture of DNA that he got from his parents. Someone who is homozygous got the same allele from both parents. In the case of the girl, is she going to have blood type A or blood type O? Well it turns out that she's going to have blood type A and that's because the A allele is the dominant allele. While the O allele is the recessive allele. When an allele is dominant that means if someone has two different alleles it will be the dominant one that wins. In this case since A is dominant over O which is recessive, A will win and she'll have blood type A. Since this girl has two different alleles we call her heterozygous since hetero means different and zygous refers to the same thing, a mixture of DNA that she got from her parents. Now I want to introduce two more terms. We can describe a person's genes in two different ways. We can look at the person's individual alleles and we call this the genotype. For this guy his genotype is AA referring to his two alleles which both code for blood type A. We can also look at a person's physical traits which we call the phenotype. For this guy and girl the phenotype would be blood type A. You can see that genotype and phenotype are different but it is possible for two different genotypes to make the same phenotype. Since some alleles are dominant over others. Let's talk about gene inheritance for a bit. Let's say that our guy and girl from before have offspring together. We can use something called a Punnett Square to determine what different genotypes their kids could have. Each of the parents two alleles are on separate chromosomes, so each parent will contribute one of their two alleles to the child. The Punnett Square allows you to determine all possible combinations. If we take the father's alleles and line them up vertically and then take the mother's alleles and line them up horizontally, we can fill in the chart to find the possible genotypes for our offspring. In this case, two of our boxes will have the AA in them and two will have AO in them. That means half of the children will have the genotype AA and half of the children will have genotype AO. Since both of these genotypes code for the same phenotype all of the children will have the blood type A phenotype. Let's see what happens if we change our father's genotype to match our mother's genotype. Now only one-quarter of the children will have the AA genotype, half will have the AO genotype since the order of the two alleles doesn't matter OA and AO are the same. One quarter will have the OO genotype. This means that 75% of the children will have blood type A in their phenotype. Since AA and AO make blood type A but 25% of the children will have the blood type O phenotype, since OO makes blood type O. What did we learn? Well first we learned what an allele is and the difference between homozygous and heterozygous, as well as the difference between dominant and recessive traits in relation to alleles. Second, we learned about the difference between genotype and phenotype and how the genotype refers to a persons DNA while a phenotype refers to the physical traits that the DNA codes for. Finally we learned about how we can use a Punnett Square to determine how different alleles will be inherited from two parents.