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So what we're going to talk about today is really why?
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intermittent fasting and low carbohydrate diets work Whereas the Calorie counters
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It just doesn't seem to work right and the problem with the calorie
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theory is [that] it's just like raw and
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Because we don't really understand obesity
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That's why we can't cure it right, so I'm sure many of you have seen this show. It's called the biggest loser and it's on
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North America, it's in Australia
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It's everywhere right and what people do is [they're] contestants that compete to lose weight, and they get put on a diet
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It's a calorie reduce diet and they do a lot of exercise, and you've seen Jillian Michaels screaming at everybody, right?
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So it's a lot of exercise, and they don't show it on the show, but there's actually a fairly severe caloric restriction as well
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It's not a low carbohydrate diet
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It's more of a kind of everything in moderation
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sort of an approach, so the problem of course is that this show has been running for a long time and
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Certain of the Contestants have come out and said well
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[you] know this really doesn't work now the reason more haven't come out is because they're essentially under a legal gag order, right?
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they're actually not allowed to say any of this stuff, but certain contestants have actually come out and
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So this contestant Suzanne said well they never do a reunion show why they've all gain that weight again
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and
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It's not it's not
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Unique to the biggest loser [a] lot of diets and we've all done these Calorie reduce diets
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it does the same for everything it does fine for about six months, but then after that it just
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Keeps coming back your weight plateaus then it starts to come back and everybody knows this right because everybody's done this diet
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The question is why?
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Right and that's what we really have to understand and that's what I mean by we have to solve the two compartment problem
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And I'll explain that in a second so the biggest loser diet despite the fact that we all know it doesn't work is
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actually ranked very highly so Usa news for example just this past year put the biggest loser diet at
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Number three for weight loss and number 11 overall so really a very good diet and why not it's a eat less move more
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Sort of approach, right cut your calories in increase your calories out and hey presto. You're going to lose weight
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So that's why it does so well because all the doctors recommended and so on
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The thing is that there have been some studies that have been done [on] these contestants, and it's very interesting to [look]
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Scientifically at what actually happens to these people as they do this sort of eat
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Less news more approach now the biggest loser of course is that approach on
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Steroids [rates] or eating a lot less, and you're moving a lot more, and that's why you get these dramatic weight losses
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So one season they actually took these contestants made them signed consents
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And then actually did metabolic studies on them and what's interesting is that at first it looks amazing, [right]?
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[and] [we've] all seen [that] show right the before on the after it looks amazing and
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the studies really bear that out, so if you look at the before [and] after if you look at the
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composition of weight loss so at week [six] and week 30 at the end of the
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Show is week 30 you can see that. They've lost a lot of weight right. This is 60 kilograms right and this is
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Fat mass so most of it is fat right everybody says [aw], you're going to lose muscle. You lose muscle another losing mostly fat
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There's a little bit of muscle loss, but it's mostly fat
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and this is their body fat percentage you can see it's follows a pretty steady trend downwards and
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the average went from
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329 pounds to 202 pounds so an amazing result right body fat [went] from 49% to
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28% so at the end of the show you get these great results
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You have the end of the show everybody wins and they pretend like everything's fine, but we know that it isn't
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And why not? What's the problem? It sounds like it should work, right?
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You keep doing what you're doing, and you'll keep losing weight
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But you don't and the reason and we've known this for [at] least a hundred years is
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that your metabolism starts to slow down, and this is what happened to the metabolism of all these contestants, and you can see in the
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Solid bar that's their baseline rate of metabolism
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Before they start at this and the open circles is that afterwards you can see that in virtually every case
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These people are cutting the amount of calories they expend by a lot
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okay, so you can look at some of these dramatic examples, so this fellow for example [list] starts out by
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Earning Thirty five hundred calories a day and he's dropped all the way to about seventeen hundred [calories] a day, right
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And it's not just him. It's everybody
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if you take the entire group of people
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the average
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Decrease in metabolism is over seven hundred calories a day
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right, so [if] you start by burning Thirty five hundred
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Which is a lot, so you start at two thousand you're going to drop down to like
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Twelve Thirteen hundred by the end of the show so you wonder why you're not losing weight?
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well
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It's because your metabolism has slowed down so much that if you're burning thirteen hundred and you are eating
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[1,500] remember that's still a lot less than you used to eat
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You're going to gain the [weight] back
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That's exactly what we all know happens
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you feel cold [you] feel tired if you're hungry, [you] feel like shit and
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The weight is going back up
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Right and that's the problem right we all know that's the problem. It's the decrease in metabolism
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So you can try to make up for it with more exercise, right?
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And that's what they pretend that you can do so you can see that baseline. There's a certain amount
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Which is resting metabolic rate certain amount of exercise?
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During the show they burn a hell of a lot of calories as exercise you see that the gram tops your total energy expenditure
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Is better but when you stop exercising for like you know five hours a day?
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Then your exercise goes down, but look at what's happened to your basal metabolism
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This is your resting metabolic rate. It's already gone down by week six okay, so don't kid yourself
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This is happening all the time
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But by week [thirty], it's gone down even or and that's the whole problem you get this
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Metabolic Slowdown and because you're not burning as much energy. You don't have that you know liveliness
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You don't feel very good
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And you can see this
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In this graph you can see this is the biggest loser contestants, and you see that the basal metabolic rate just keeps on going down
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But there's a similar
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Extreme measure that doesn't seem to have this problem and the question is why?
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So you can look at bariatric surgery so bariatric surgery is stomach stapling surgery, right?
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So you cut your stomach into the size of a walnut you
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Really just can't eat and you can't eat for months and months and months and guess what the weight goes down, right?
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That's not a surprise
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the surprise is that it works to keep weight off in the long term yeah, there are a lot of problems with this okay, so
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Let's be clear. I'm not recommending it for anybody, right?
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but if you look at the resting metabolic rate
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with a similarly sort of extreme measure it goes back up the
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[question] is why so this is another?
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Study of the long-term effects of bariatrics and you can see that a baseline and a follow-up. This is several [years] [later]
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The resting metabolic rate and the total energy expenditure how much energy you're burning has really not gone down
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Right as opposed to the eat less move more where it keeps going down keeps going down until you fail, right?
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That of course is the saddest part of all right the saddest part of the entire thing is that we know about this
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metabolic slowdown this was shown in
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1915 so we've known about it for a hundred years
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what I think is sad, is that we give people this really horrific advice to eat less and move more and
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Then when they fail, we blame them for it
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Right and that's basically. You're blaming the victim because here's this poor fellow or poor lady
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Who's victimized?
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Because they're suffering from obesity from type 2 diabetes you give them really bad advice
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Which you know is going to fail because we've all done it it fails every single time and then when the weight goes back
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You say yeah, you should have listened to me better. You should have had more willpower
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you shouldn't have eaten that bagel or whatever it is you tell people right and that's really the saddest [part] of all is that we
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Try to pretend that the advice that we give is really good and the failure lies with all of you
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Right, but doesn't doesn't make any sense right? How can like?
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forty fifty percent of the population
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Be so morally bankrupt that they let this happen to them is it not more
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Logical that the advice that we gave was just really crappy that seems to me much more sensible
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So we're going to explain why this
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sort of discrepancy exists
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So in order to do that you have to understand what happens when you eat, okay?
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[so] what happens when you eat? Is that insulin goes up? So most foods almost all foods have a
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mixture of macronutrients [fat]
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Carbohydrates and protein so your insulin goes up to a varying degree and insulin
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Basically is the hormone that [tells] your body to store fat
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So it stops your body from burning fat you start to store some of the sugar and store some of the fat
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Okay, and this is normal. This is a normal situation
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so
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Carbohydrates get turned into glycogen which are chains of glucose so chains of glucose in the liver?
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Is basically a storage form of sugar okay? And when you have too much of that then your liver produces?
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Lipids which is called
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De Novo lipogenesis, and it basically stores fat okay, so when you don't eat when you're fasting
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So fasting is merely the absence of eating your insulin levels fall
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And that's a signal to start pulling some of that energy out
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Right so you're going to start by pulling some energy out from the glycogen
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Which is your stored [sugar]?
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And you're going to pour some pull some energy out [of] the stored fat so you can think of it the glycogen
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Like a refrigerator right you're storing food energy
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And the reason it's like [a] refrigerator
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Is that it's easy to access so [you] can get put food in easily you can take food out easily, right?
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It's just food energy and the fat is more like your freezer
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Okay, so you can store more of it, but it's in your [basement]
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You know it's hard to get to it's hard to get out
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It's hard to put in so you generally prefer to use your refrigerator
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and it's the same idea you have two storage forms of energy one easy to use and one not so easy to use the
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refrigerator though has a limited capacity
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[so] if you put if you have too much stuff you have no choice
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But to put it in your freezer
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Now the reason that the calories don't work is that they operate on what I call a one compartment model
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Okay, so that means they pretend that all your calories goes in to your body
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And it's all the same all your calories are the same
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they're stored in one giant compartment like this sink and
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When it comes to taking out energy it all comes out of the same thing
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right therefore if you follow this sort of very simplistic
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Incorrect model what you see is that if you simply reduce the calories going in?
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You'll reduce your weight and if you increase the calories out you'll increase the rate
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but the entire premise of this sort of calories in calories out model is
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completely fictitious
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because we know that's not what happens in the body the body doesn't have some giant vat of
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Calories right you can store sugar you can store fat. It's not some giant vat of calories
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That's held somewhere in your liver, right?
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But that's what they all pretend it is so if you have the entire wrong idea of why this should work?
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Then it's not going to work
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What instead is?
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A better model is a two compartment model that is there are two places in the body where you can store food?
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You've got your fridge
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And you've got your freezer your calories goes in into your fridge calories goes
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From the fridge because that's the easiest place it goes, but there's a third thing that you have to consider
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And that is how much food goes back and forth between the freezer and the fridge because that's what we're really interested in
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this
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the fat, but that's the one that's much harder to get to
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Right and the question is what's controlling this?
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because that's really the key and
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It turns out that the main player is insulin we know this because insulin
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inhibits lipolysis
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Right what that means is it stops you from getting the fat coming out? That's a job
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That's a normal job. So if you have a lot of insulin
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right so normally if you eat a huge meal your insulin is high it's going to tell the body to move all the
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Storage in this way if your insulin is very high then you can't get the food back out this way
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And that's the problem
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So if you have a lot of insulin resistance for example which keeps your insulin levels very high it's like that
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Freezer is kind of locked away in the [basement] behind the lock you know steel bar. You can't get at it
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so what happens now when you start reducing your calories if
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you start reducing your calories in and
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You can't get at your storage
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What your body is simply going to do is reduce the calories out?
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That's what it does right because it's not going to keep losing weight until you die
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That's just ridiculous right, so if you look at the women's health initiative
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Which was a huge fifty thousand person study. They reduce calories by
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[350] Odd
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per day for like seven years and they estimated that
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People would lose 30 pounds women would lose 30 [pounds] per year
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Right so in seven years. They should have lost 210 pounds right of course that didn't happen
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[how] much did they lose not even a single pound it was ridiculous because?
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What happened of course is that their body is if you're not affecting me in insulin you can't get at that fat?
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You're just going to reduce [your] calorie though, and notice here of course that we're not breaking any laws of thermodynamics
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right
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Calories in calories out yeah, you're accounting for all the calories
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[but] what's important is the compartmentalization of energy right?
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That's what we're talking [about] not the total energy, but where it goes
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Right because that's what we want to know if you eat, and you just burn [it] off
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Who cares that'd be great?
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But if you eat and all of it goes into fat well now you care a lot, right?
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But it's not that calories [are] imbalance if you eat an extra 500 calories your body burns it all off as fat
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Bob burns it all off as heat. Yeah who cares you don't have any extra body fat, but if you get 500 extra calories
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Boom the insulin is telling it all to shunt into here. Well, that's a problem and
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That's really the problem of the two compartment syndrome
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So if you look at what happens during fasting?
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What happens because everybody worries about this right? Oh, what [about] protein you're burning your muscle, right?
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So this is a study by Kevin Hall
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from the nih
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And he basically looked what happens during fasting and this is what happens, right?
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So for the first couple of days of fasting what you see is that carbohydrate oxidation goes off?
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It goes way up right in other words. You're burning sugar you can see that fat doesn't actually move for a couple of days
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You're not burning a hell of a lot of fat
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Right and then as you run out [of] the glycogen remember that the glycogen is
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You're easily accessed energy, but limited in terms of how much you can store once it all burns out
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then look
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Fat oxidation goes off now. You're burning fat for energy
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That's perfect that's exactly [what] we want to do, but what happened to protein are you burning muscle?
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Hell, no, it goes up slightly, okay at the very beginning then drops
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So protein is not a storage form of energy
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Why would your body burn it for energy, right?
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You hear this argument all the time you're going [to] burn muscle
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Right so it's ridiculous right because you're telling